# Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia ## What is Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia (CANVAS)? Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is a rare, late-onset neurodegenerative disorder that affects the cerebellum, peripheral nerves, and vestibular system. ## Symptoms of CANVAS CANVAS typically presents in middle life with symptoms such as: - Difficulty walking and coordination - Tremors - Slurred speech - Hearing loss - Tinnitus - Vertigo - Nausea and vomiting ## Causes of CANVAS The exact cause of CANVAS is unknown, but it is believed to be caused by a combination of genetic and environmental factors. Mutations in the RNASEH2B gene have been linked to CANVAS in some families. ### Diagnosis of CANVAS CANVAS is diagnosed based on a physical examination and neurological testing. Blood tests and genetic testing may also be used to confirm the diagnosis. ### Treatment of CANVAS There is no cure for CANVAS, but treatment can help to improve symptoms and slow the progression of the disease. Treatment options include: - Physical therapy - Occupational therapy - Speech therapy - Medications to manage symptoms such as tremors and nausea - Surgery to correct hearing loss or balance problems
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